Hi John,
The settings in your sim have changed, perhaps because you have installed a new joystick or yoke(?!?). Go into your SETTINGS > CONTROLS and then make sure you see the CONTROLS for your joystick or yoke or pedals. Then you can change which axis does what (turn left, right, etc). You can assign anything you want so if you'd rather use your throttle lever to go up/down, then assign that movement to that axis ... BUT beware that if your throttle is not at ZERO when you go into slew mode, then your aircraft will go straight up! (or spin around, or move far away to the left, or whatever